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Stormy Leigh O’Bryant

Stormy Leigh O’Bryant

DCH Health System, USA

Title: Advancements in neonatal surfactants

Biography

Biography: Stormy Leigh O’Bryant

Abstract

Background: Respiratory distress syndrome (RDS) is the major cause of neonatal respiratory distress. RDS results from lung immaturity in pre-term infants as a result of surfactant deficiency and is associated with increased morbidity and mortality among this population. Purpose: Update neonatal providers on advancements in surfactants for the management of RDS. Objectives: Review latest primary literature for natural and synthetic surfactants indicated for the management of RDS. Discuss efficacy and safety data for the pipeline surfactants, aerosolized KL4 surfactant (AEROSURF®) and lyophilized KL4 surfactant (SURFAXIN LS™), currently in early phase clinical trials. Discuss the variances in delivery methods and neonatal tolerance among natural and synthetic surfactants and possible advantages offered by these pipeline surfactants.