Pediatrics

Biography

Biography: Khaled T. Muhammad

Abstract

Background: The risk factors of childhood obesity include; energy intake, positive family history and lifestyle. Obesity is associated with numerous co-morbidities such as cardiovascular diseases, type 2 diabetes, Objective: to study the effect of obesity on some myocardial functions and lipid profile. Design: 9-months prospective case controlled study. Setting: Pediatric Department Tanta University Hospital Patients and Methods: 30 patients were included 24 males and 6 females; aged 6-15 years with BMI ˃ age and sex specific cut off points. Exclusion criteria included organic causes of obesity, hormonal medications, corticosteroids, hypertension & diabetes mellitus. Twenty healthy children with matched age and sex set as a control group. All studied children were subjected to: Anthropometric measurements: weight, height & BMI. Echocardiographic evaluation; LVEF, LVFS, LVEDD, predicted LVEDD, %LVEDD, LVM, LVMI & LMPI. Lipid profile assessment included serum TCh, LDL, TCh / HDL ratio & TG. Results: there was highly significant increase in body weight, serum TCh, LVEDD, LVM & LVMI. There was significant increase in BMI, LDL, HDL, serum TG, TCh / HDL-cholesterol ratio, %LVEDD, predicted LVEDD & LMPI of obese as compared to controls. There was no significant difference between the two studied groups as regards height, LVEF & LVFS. There was significant decrease in HDL in obese as compared to control group. Conclusions: LMPI is an early echocardiographic detector of LV global dysfunction in obese children. This; in combination with lipid profile must be included in routine evaluation and identification of the high-risk obese children in addition to weight-control/reduction. It is recommended to clarify the effects of obesity on cardiac function and lipid profile in infants and young children