Zareen Fasih
Gulf Medical University, UAE
Title: Emergence of multidrug resistance Enterobacter sepsis in a neonatal tertiary care setting: A three year study
Biography
Biography: Zareen Fasih
Abstract
Objective: To study risk factors for Enterobacter sepsis and sensitivity pattern of the organism.
Method: Prospective hospital based study conducted at tertiary neonatal intensive care unit of Ziauddin University Hospital from January 2011 to December 2014. Blood specimens for culture from 2166 babies were sent. Repeat cultures done when the neonate did not show improvement or deteriorated on first line antibiotics. Risk factors were looked for. Antibiotic resistance of the isolate was studied by the disk diffusion technique.
Results: There were 540 (24.93%) cases of culture proven sepsis. Enterobacter was grown in 84 (15.55%) cases. Among the gram negative organism Enterobacter was the commonest organism n=84 (15.5%) followed by pseudomonas n=54 (10%). Among the gram poansitive orgism, Staphylococcus lugdunensis seen in 150 (27.77%) cases followed by Staphylococcus aureus n=54 (10%). Increase incidence of late onset sepsis (4.6/1000 live births) was observed during this period. Univariate analysis of risk factors revealed a significant association between LBW 54 (P value=0.001), prematurity 78 (P value=0.001) and prolong stay 66 (P value=0.001) and Enterobacter sepsis. Resistance to the first line antibiotics (Cefotaxime sodium, Aminoglycoside) was seen in 72% of cases.
Conclusion: Prolonged stay in the nursery due to prematurity/LBW is important risk factors of Enterobacter sepsis. Prolonged use of antibiotics results in emergence of multidrug resistance. Further studies are needed to establish the role of antibiotics in the emergence of multidrug resistant microorganism.