Yasser K Rashed
Menoufiya University, Egypt
Title: Post-dilatation application of mitomycin-C in children with esophageal strictures
Biography
Biography: Yasser K Rashed
Abstract
Background: The esophagus is the major site in risk for strictures in the upper gastrointestinal (GI) tract. Narrowing of the alimentary tract in children is almost caused by a benign disorder (e.g., peptic or caustic). Endoscopic management of alimentary strictures based on the ability to gain access to the narrowed segment non-surgically. Clinical responses to the topical application of mitomycin-C in reducing scar formation had been reported.
Aim: To evaluate the methodology, efficacy and side effects of mitomycin-C application in the treatment of esophageal strictures.
Patients & Method: This study included 30 children. Upper GI endoscopy was done until reaching the stenotic area, esophageal dilatation was done and then re-endoscope the patient and mitomycin-C applied topically under direct vision.
Results: The response to mitomycin application was excellent (both clinical and endoscopically) in 28 patients (93.3%) and good (endoscopically only) in 2 patients (6.7%). Mitomycin application resulted in no complications in both studied group.
Conclusion: Esophageal dilatation followed by local mitomycin-C application may be a useful strategy in esophageal strictures especially those refractory to repeated endoscopic dilatation.