Mehrdad Modaresi
Islamic Azad University, Isfahan, Iran
Title: The Effect of Lavender Hydro Alcoholic Extract on Liver's Enzymes and Histology
Biography
Biography: Mehrdad Modaresi
Abstract
The liver has a key role in the regulation of many physiological phenomenon. Due to the use of traditional medicinal plants, in this study the effects of lavender (Lavandula officinalis) extract on tissue and liver enzymes were investigated. In this experimental study, 50 mature female mice were divided into 5 groups, each group including ten adult female Balb/C mice. The control group did not receive any extract, the placebo group received 0.5 cc normal saline every other day and 3 treatment groups received hydro alcoholic extract of lavender with 50,100,200mg/kg /2day doses that was used interperitoneal injection for 20 days..20 days later, blood samples were taken from all groups and the liver enzyme ALT, AST, and ALP were measured. Liver tissue was studied by light microscopy in all groups. Obtained data were analyzed using SPSS program (p<0.05). ALT enzyme increased significantly in 200 doses (p<0.05). AST enzyme levels at doses of 100 and 200 mg/kg compared to the control group showed a significant decrease, and ALP enzyme concentration in a dose of 200 compared to the control group showed a significant decrease(p<0.05). Observations in sections showed that the liver tissue in 50 and 100 were not significant pathological changes but obvious pathological changes of liver tissue (necrotic tissue) observed in 200 group.