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Xiaoyan Wang

Xiaoyan Wang

Hubei Maternal and Child Health Hospital, China

Title: Bone Mineral Density of the Spinein 11,898 Chinese Infants and Young Children:A Cross-Sectional Study

Biography

Biography: Xiaoyan Wang

Abstract

Background:  Bone  mineral  density  (BMD)  increases  progressively during  childhood  and  adolescence  and  is  affected  by  various  genetic  and  environmental  factors.  The  aim  of  this  study  was  to  establish  reference  values  for  lumbar  BMD  in  healthy Chinese  infants  and young  children  and investigate  its influencing  factors.

Methods and Findings:  Healthy  children  aged  0  to  3  years  who  underwent  regular  physical  examinations  at  the  Child  Health Care Clinic  of Hubei Maternal and  Child Health Hospital  (N = 11,898) were recruited for this study.  We also chose  379  preterm infants  aged 0 to  1 years to preliminarily  explore the development  of BMD in  this special population.  BMD (g/cm2)  measurements of the lumbar  spine (L2–L4) were carried out with dual-energy  X-ray absorptiometry and a questionnaire was  administered  to  full-term  children’s  parents  to  gather  information  on  various  nutritional  and  lifestyle  factors  as  well  as  mothers’ nutritional supplement use  during pregnancy. Lumbar BMD significantly increased  with age among both boys and  girls  (p,0.05), with  fastest growth  observed  during the  first postnatal  year.  There was  no significant  difference  in lumbar  BMD between  boys and girls  of similar age  (p.0.05), either among  healthy reference children or  preterm infants. However,  BMD  values  in   preterm  infants  were  significantly   lower  than  those  in   term  infants  3  to  8   months  old  (p,0.05)  after  adjustment for  gestational  age. Multivariable  linear regression  analysis  indicated significant  positive associations  between  lumbar  BMD  of  healthy children  and  the  child’s  age  and  current  weight,  mother’s weight  gain  during  pregnancy,  birth  weight,  children’s outdoor  activity duration  and  children’s physical  activity duration.

Conclusion:  Our  study  provides   reference  values  of  lumbar  BMD  for   healthy  Chinese  children  aged  0  to   3  years  and  identifies several  influencing  factors.